My reaction to Wellbutrin (which I'm on now at 150 mg--I think SR?--with Zoloft) is similar to what I had physically with Cymbalta and Effexor--they all affect neurepinephrine, so it makes sense. It's hard to describe though. I have a certain feeling when I take Tylenol, where...I don't know it's like my muscles and head feel kind of weird. It's difficult to describe. It's not a pleasant sensation for me, but not actual pain per se. I want to get off the Wellbutrin because it's giving me that effect. (Thankfully, I haven't had the psychological side effects I did with Effexor or Cymbalta, or I'd have been off it shortly after I started.) I feel like it's interfering with my sleep too.