When I first started Seroquel 2 years ago, for the first 6 months I had to take it literally AT bedtime. Within 4 minutes I almost couldn't stand up & I certainly couldn't walk. Now I can take the Seroquel an hour before bedtime and I'm lucky if I fall asleep fairly quickly & stay asleep all night.

This thread is interesting because it really shows how wide the range is...how differently people react to the same medication.