What is the difference between Wellbutrin SR and XL? They are both Wellbutrin but the difference lies in how the tablets dissolve and are absorbed, as such they have slightly different effects on the body.

The main difference between Wellbutrin SR and XL is the release potential of the tablets and therefore the dosing schedule. In general, Wellbutrin needs to be taken three times daily, Wellbutrin SR needs to be taken twice a day (slow release), and Wellbutrin XL only needs to be taken once per day.

It often boils down to just how your body metabolizes medications. Mine for instance, processes everything very quickly and when I take any meds I have to take higher doses in general.