I just started Sam- E along with a high dose vitamin regime for my mental issues; mostly add, anxiety and paranoid symptoms. Since I just went off wellbutrin and have had withdrawals I can't say for sure how it's working but I do notice a difference in my ability to function and less anxiety. I also take 50mg 5htp twice a day and that is helping as well.
After a couple months I'll update to let you know how it's going..it is expensive but I just ake one capsule of sam e a day