I've been on Cymbalta for several months. It is the best med I've taken so far... I've been on Zoloft, Paxil, Buspar, Wellbutrin in the past.

It takes 3-4 weeks to take full effect, but you should notice some difference almost immediately.

As for weight gain, it probably depends on the individual, as drugs affect everyone differently. I've had no problems whatsoever with weight gain. If anything, it is a bit of an appetite killer for me.