Up to two thirds of people with major depression will not respond to the first medication. The definition of treatment resistant depression is not uniformly agreed upon. However, one definition is that depression may be considered resistant to treatment when at least two trials with antidepressants from different pharmacologic classes fail to produce a significant clinical improvement. But that does not mean you will not be helped by pharmacology at all or by other treatments. It is definitely not time to give up or to think that you do not have options just because your p-doc said that. I have not been given that diagnosis but what I suggest is that you learn as much about the condition and about yourself as you can. That way you can answer your own questions.