I get the super irritation and intense anger too. More often than not, it starts for me a bit later in the day too. My theory is that people with bipolar are more sensitive to weather changes and time of day. But anyways, I would say go ahead and take that 2nd dose at 4pm. That's not too far off. Stay hydrated. Maybe take it with a big glass of water and a bit to eat. Maybe even take it with dinner. If taking it with food doesn't help, I would suggest talking to the doc.