My best girlfriend takes like, 300 mgs a day. She had to seriously adjust the timing b/c she simply could not function like that. It is interesting, my mother who is paranoid schizo takes close to 900 mgs of seroquel, AT ONE TIME, and it does not bother her at all. She doesnt' get sleepy one little bit. Lower dosese are often used to treat insomnia (I used to take 25 mgs at night to help sleep).

I would suggest, of course, talk to your psychiatrist, but also talk to your pharmacist. They tend to know MUCH more about the interaction of the meds and timing issues than the pdoc often does. See what he has to say.