Well last night was my first dose. It worked like a charm! I know they told me it wouldn't necessarily work overnight BUT.....I have a very sensitive system to different drugs & already, I slept through the night for the first time in 3 weeks & my mind is not racing anymore. So, despite what they said about it working overnight, I think it may actually be doing just that. I feel better already & I hope this is the Seroquel doing that for me.