My nightly regimen is lamotrigine(=Lamictal) and Seroquil, which I take whether or not I've been drinking. It'll make me pretty tired about a half hour after taking them, but I haven't had any rough experiences with it.

That being said, these days I max out at 7-8 drinks spread out throughout the evening. I haven't gotten schmammered since before going on the meds, so I can't speak to whether it's safe or not to cross them while wasted.