I have a friend who is bipolar and went off her meds for 10 years before having a very destructive manic episode. She was very depressed for at least the last couple of years. If you're bipolar, it's possible to be off meds, but once you hit the wall only meds will bring you back down. There is no cure.

Borderline PD also features emotional dysregulation, but the goal is to prescribe medication over the short term and focus on DBT as a treatment.