I gained 40 lbs. in 4-5 months on Depakote. I was on Seroquel twice. The best AP so far for me, stabilized and slept like a baby. I couldn't stop eating. The second time pdoc added Topamax to stop the cravings but that **** makes you as dumb as a box of rocks. Seroquel caused me to be pre-diabetic so I came off of it I think six months ago. Tried to just be on lamictal but had my first experience of psychosis so I just started Geodon two weeks ago. I will be going up to 60 mg tomorrow, so it's not at a therapeutic level yet. I'm still hypo and doing semi-better at sleeping. It's weight neutral, and I haven't had any problems. I understand your frustrations. I've lost 70 lbs over the past 2 1/2 years when I've been off of Seroquel, and put on thyroid meds. Forty pounds when off Seroquel. So yeah, in a nutshell I get it.