Yes, meds work great for me. I have never had an "episode" of depression - it's been lifelong. My behavior never changed, it was always severely depressed, from early childhood. Purely genetic depression seems to be sort of unusual but it happens. Runs in my family going back 3 generations at least.

I've had meds poop out on me. Lexapro only worked for a couple of years. You should talk to your doctor about that.

I would think therapy COULD help with unhealthy behavior patterns though.

Do you think it's possible the depression was actually an early manifestation of your auto-immune problems?