It took a long time for the Zoloft to work for me, but now that I'm at 300 mg it works like a charm. I worry about going off of it since I'm on such a high dose, though. Still, I wish you the best of luck! It's worked for me as we as many others so hopefully it'll work for you. If it doesn't, though, don't be discouraged because that's the way these drugs work. You've just gotta find the right one.