i gained a small amount of weight on seroquel. the first round of wellbutrin did the same to me as to you, minus the hair loss. I was not on seroquel at that time, however. the wellbutrin did lower appetite quite a lot, it was not an issue to forget a meal or only have snacks after breakfast. weight fell off, but once i stopped it and had a horrid summer, I gained so much more. I started it again about 2 1/2 months ago, and some weight is gone. i guess it just really depends on other interactions with meds and what you're doing. the first time i was exercising more than I am now while again on it. i hope you can find some foods that taste good, to provoke appetite.