think it's a catch 22, can the weight gain itself make you depressed? I have been overweight most of my life, not even due to meds so when my doc wanted to put me on Zyprexa I absolutely refused. I am glad I did because all the meds were starting to make my problems worse. But as one poster said this is not an option for everyone. I think it's important to be on the lowest effective dose and exercise regularly. Until better treatment is found, options are tough. I would say stay healthy as you can and learn to love yourself, I happen to think a large confident woman is one of the most attractive things there is.