I'm not a Dr. so check with one on this it might be the Wellbutrin not the Lamotrigene causing the numbness. I had a negative reaction to Wellbutrin and my therapist said it was bad for bipolar disorder. So I'm now on Seroquel and Lamotrigene and outside of some drowsiness from cycling it in its making me feel better. Maybe see if it's just a bad mix of Meds.