I've been on doses varying from 800 to 1200 mg. I took it for unipolar depression. It didn't work. By some miracle, I didn't get toxicity even though I didn't drink for a couple of weeks while on it (I did eat a litre of yoghurt a day to get some liquid into myself) (I was psychotic and basically thought drinking would make me immortal - and given that I was suicidal, that wasn't what I wanted).