I've been on lithium for a year. I'm currently taking 1500mg and have no side effects other than increased thirst. I have to take it with food or it will upset my stomach. Wellbutrin made me crazy but I'm doing well on 120mg of Cymbalta. Lithium is my wonder drug. It took away the suicidal impulses I had during mixed episodes and allows me to be on an antidepressant.