Well, I went up to and including a leg amputation - but that wasn't just for the pain, it was also because the illness was progressive (if they didn't amputate right then and waited a couple of months, they'd have to amputate even more of my leg) and because it could turn life-threatening any moment. And I didn't have a choice - doctor told me that if I didn't agree to the amputation, he'd have a judge declare me unfit to make my own decisions and force me that way, and if my parents disagreed (I was 15 at the time) he'd have them declared unfit guardians.