Hello WorkhorseDVM: I'm sorry to read that you are having such difficulty. I would presume that the ups & downs you're experiencing are to be expected, to some extent, for a person with your diagnosis. But then, of course, having your meds changed certainly makes everything that much more difficult too, until you've adjusted to the new med's. I would like to send some warm thoughts your way with the hope that you will be able to find your way through your present struggles to a new more peaceable place...