I've discovered through forgetting to take my meds that I'll be fine for 2 days, but then hell breaks loose. I had to immediately take a little bit to get past the curled up in a ball part over with.
So for me, I'd save the last one, and as soon as it got bad- which was pretty damn quick after 2 days, I'd take half of one to make it through, then the rest if I don't get better.
If it got really bad, I'd get to an ER and have them dose me.
Good luck!