I've been on it for about a month and a half. I felt a difference around day 20-25 with the 50mg dosage. Now I"m at 200mg and it is glorious - I have my energy back, my thoughts are positive, and I am interested in hobbies again. Watch out on missing a dose though, when I did it sent me down fast and I didn't recover until 3-4 days later. Best of luck to you!