We as in my husband and I decided we needed a night out and were invited to a birthday party for a friend. As I said I had not drank in over 18 months due to pregnancy and birth of child number 4. and we only drink normally 2-3 times a year. Drink, no meth no addictive behaviors just a night out with the hubby for some drinks. I've been clean for 15 years and never plan to go back. All I wanted to know is the correlation between alcohol and depakote. Chemically why did it affect me like that? Why did the alcohol not affect me when I know two drinks is normally enough for me? Why did it make the rls and plmd so bad. I think the not sleeping was just due to my rls. It's impossible to sleep when the symptoms get bad like I have them. So once again I am an addict that has been CLEAN for 15 years. This is purely a question of how does the alcohol and depakote interact. I tried to make that clear. I have a need for knowledge when I put anything in my body.