My guess is that it woud have to do with depakote being heavily processed by the liver as well as alcohol. Maybe the depakote takes up the liver's resources? I don't know but there is probably some connection to the liver. Which means drinking and depakote really don't mix well. Not criticizing, I understand what you want and am not trying to do that, I just know that after being on depakote (high dose) for a while I started occasionally having high liver values and would have to be checked again and would be fine and then 6 months later I'd be slightly high and get a recheck that was fine. It was never a big deal,just an extra lab, but I do know that depakote can test the liver's capacity. I think that almost all of it is processed in the liver without being processed in the kidneys at all.