God first uses His Word to speak to us, the Bible. He also uses the Holy Spirit within us, to urge us and help us to know what to do. He uses other people to tell us and encourage us to do what He wants us to do, with discernment from reading the Scriptures and the Holy Spirit's inclinations within us.
There are days when I can't function well at all, and ask God to direct my day, telling Him that I will accept everything that happens that day as His will.