Hello jtassar93: You know... people's reactions to med's, as well as to not taking them on time, are so individual I kind-of doubt you could really say what is normal. Personally I've gone on-&-off med's, & forgotten to take med's, & never had any real difficulties. But I've also read posts written by other members here who have had quite a bit of difficulty even if they just missed a dose by a few hours. It sounds like you are more in the camp of people who have had difficulty. Hope you do not have to go through this again! Best wishes...