Yes. In fact they just changed the clozapine/clozaril registry and prescription/blood lab requirements and more changes coming early next year from what I understand. I have a family member on this med for the last year. Started with a very slow taper-up (it can kill off your white blood cells and antibodies which is why the blood tests and caution), weekly blood tests for 6 months, bi-weekly for another 6 months and then monthly.

We also had some issues with the pharmacy prescribing klonapin -- they would not do it because of the possible interaction.

The clozaril had a sedatating effect each time the dosage was increased that took a while (days/weeks) to adjust too and still remains a bit as far as I can tell, it never completely goes away.