Perhaps read (and contribute to) the existential thread that was recently started. You have some good thoughts here.
The reality is that this world is finite in its ability to sustain life. It is interesting that you imagine all perishing in a fire. Most likely the opposite will happen, because the universe is expanding out, our world we drift further and further away from the sun and lose its heat source.
We reflect the universe and the universe reflects back. While all kinds of things are happening on a large scale, mindfulness brings us back to the immediacy of the moment, which is all we really have.
Since I am doing a holistic healing path I don't have medication to blunt the edges of reality. On the other hand my senses are more sharpened and I can appreciate all the moments I am experiencing.
I don't know if this helps. When I am not grounded in the moment and making meaning out of my life moment to moment I can easily spin out of control mentally and emotionally and feel that the big picture is meaningless.
The only way I know to get back to some peace of mind is to first ground myself solidly in the moment, and to seek out meaningful social interaction. Love is a balm for the aching heart.
I really liked your post, your thoughts, and feelings. You seem like a really sensitive person. I hope you find relief, and that you report your findings back to PC so we might all benefit.