dustin, i agree with christina........ there is situational depression, like if you lose a loved one or go through a traumatic experience, and then there's depression caused by chemical imbalance. whether it's med-resistant probably depends on the person. both depression and anxiety run in my family, mom, uncle, sister, cousins, lots of my relatives (as well as myself) have struggled with it. it gets worse when the bad things happen, like losing loved ones, etc, but it's pretty much always been there - like you, i've been sad since i was little. i'm sorry your meds aren't helping but it sounds like you have a good thing going with your new T....... like echoes said, it sounds like therapy will be very good. good luck and hugs......