The clozaril has helped in our case significantly. The thing is that it can cause problems with immune systems - white blood cells and antibodies and you much have constant blood tests to make sure all is okay. You also have to be registered in the Clozaril registry and blood tests filed in order for meds to be issued. This part is something of a pain but that's just the way it is.

The reason for slowly tapering up on the dosage is that the adverse effects on the immune system must be monitored with blood tests to make sure you are tolerating it.
I suspect it is best to do this inpatient and can't imagine doing it on an outpatient basis, but I guess it depends on the severity of your symptoms.

There is lot of information at the Clozapine registry - https://www.clozapinerems.com/CpmgClozapineUI/home.u

and at the various drug sites online.

They have made significant changes to the requirements during the past year that we have been using it and I understand new changes will go into affect next year that will require pdoc review of the blood test results (not just the pharmacist) in order to fill the meds.