My psychiatrist is a leading dr at one of the top hospitals in the world. She specializes in hard to treat cases and is both a pharmacist and a pdoc so she really knows meds well. She (and many other pdocs) are quite comfortable using up to 1500 mg of Seroquel in treatment resistant patients and while it's not done particularly often it is not incredibly unusual either, especially for someone in my position which is that I had run out of all meds that could work safely except for Clozaril and we were trying to hold out until a new med came out that would work. We didn't make it that long, so I'm starting Clozaril and there is no good med to have as a fallback if it doesn't work. I've been on 69 med combinations (not including dose changes) because I'm hypersensitive to some meds and hyposensitive to others. Clozaril will be 70. It is accepted enough that I get Seroquel through patient assistance and they have provided up to 1500 mg per day without any questions or issues.

My pdoc is completely capable of making decisions for my care and honestly so am I; I would not take something I did not feel was safe and I'm a healthcare professional so capable of reading drug profiles and research articles.

Thanks for your concern though.