I suffer from MDD, anxiety, mood disorder (s).
I have tried so many meds for the depression and with me, the problem is that I get over stimulated to the point wear it gives me even more anxiety. I have an extremely low tolerance to most medications.
I'm currently on cymbalta and it helps with nerve pain that I suffer from, and it's not too bad for depression but even trying 90 mg's I'm on the over stimulation line. I can't take more than 60 mg's, I know people that take twice that and it doesn't bother them.
I've tried brintellex which was good for 3 weeks until it caused severe anxiety and manic episodes.
I take lamictal now for mood disorders, and at least that works well. I also take trazadone for sleeping, works good but I'm a zombie in the morning. So I try to take a little bit less, then I don't sleep.
For anxiety I take klonopin which i've been on for over 20 years. I started taking it in the 90's when they seemed to be handing it out like candy. My maximum dosage was 8 mg per day. I wish I never got put on that. Of course it helps, with the least side effects. The addiction to it is horrible though. I now take 2.5 m and am very slowly trying to wean down a little more.

It's been a rough road trying to find the right meds. I think I am going to tr the rexulti. I don't like being a guinea pig........... but..... ?? I'm just hoping I don't get the over stimulation from it. AND the Dr. did say to take it at night with my other meds......... I don't know.