Clozail was the first atypical antipsychotic. It is high potency and is widely known as one of the best antipsychotics, even for those who are treatment resistant. However, because of the risk of a rare auto immune disorder (that can result in death if not seen), you must have blood drawn weekly for 6 months, biweekly for 6 months, and then once per month for as long as you are taking the med. That part is a pain in the ***.