I've pretty much been alone my whole life, no friends or significant others, and lately I want something more,

Have you wanted to be alone in the past? What changed now that lately you want something more?

but realize that that's likely never happening, since I've tried my whole life to make anything at all happen, and it still hasn't.

What have you tried? Why do you think you weren't able to make friends or lovers?

So what can I do to lessen the feeling that accompanies being by myself?

What is that feeling?

I could literally go weeks without talking to, or seeing anyone and no one would notice or care if they didn't notice me either.