I have suffered with Depression for over 40 years, been through all the Therapy and meds and currently maintain a level between Severe and Moderate Depression with the aid of Mirtazapine.

For the past few months I have been spiralling ever lower and I finally brought it up with my GP yesterday. She increased my dose of Mirtazapine greatly, which I started last night.

Exactly 12 hours later my Mood plummeted to what can only be described as abject despair. Rarely have I been this low, and it has never 'switched on' like this. It has barely eased or elevated since. I have never had this effect from an AD change or increase before.

Would you all say this is a result of the Mirtazapine increase, or simply a co-incidence and just a continuation of my worsening Depression.

Dave.