I've been taking metformin with bipolar meds for a long time. It helped me lose 40 lbs in the first couple of months and then kind of stopped helping me lose but it helped with appetite still. I stopped taking it a couple of months ago (dunno why) and I'm restarting it now and it's making me nauseous (that's one of the side effects) but I am hoping it will help me lose weight again since I've been off it for a while.