To further complicate the situation, the wide variety of antidepressant medications can affect different people in very different ways; a drug that works for you might do nothing for me and then crush me with withdrawal symptoms when I end my unsuccessful trial, others might suffer intolerable side effects that you don't experience on the same medication, and a drug that works for you for months or years could suddenly or gradually lose its efficacy as your brain adapts to it or your underlying disease changes. You have to work with an experienced and flexible psychiatrist who is willing to work with you to find the medication or combination of medications that works best for you. I enjoy reading love letters to Latuda on this forum because when I tried Latuda it threw me for a loop. Last year I tapered off Wellbutrin even though it had seemed to help in the past, but I had felt so badly for so long at that point that I decided that it couldn't possibly be helping me anymore.