When I was younger nothing touched my depression and I didn't cycle typically as in bipolar but I may have experienced mixed moods. But for decades nothing helped lift the depression until prozac came out. It didn't take the depression away but it did give me the ability to finaly utilize therapy for a better quality of life. I also took an AP along with it.

30years later I live in the south n all the sun has pushed my more or the hypomanic side of stability. M on a very minimal dose if paxil. Pdoc reduced it last viditt. May take me off it next visit. For 40+ years I was diagnosed MDD. Now I am diagnosed bipolar. Seroquel is finally stabilizing the rapid cycling I was experiencing down here. But meds without therapy also don't work for me. Neither does therapy without meds.