I've been on up to 600mg in seroquel a few years ago for the antipsychotic affect. I was put on 100 mg for anxiety then upped to 200mg for sleep now 400 mg for agitation well mania/hypomania anger type stuff from what I understand... what has seroquel helped you with? What can it help with? What is an appropriate dosage? I had my dosage upped bc the doc didn't feel comfortable I assume with the fact that I said if someone said something to me the wrong way I didn't know if I was going to be able to... handle myself appropriately basically.