I am on a very high dose of Seroquel (and tried even higher months ago) and it is just no longer working for me. I've tried every other atypical that I'm either not allergic to by default b/c it is a derivative of something else I'm allergic to or it doesn't cover my symptoms well enough, except one that I can't get samples to try and I can't afford it on Medicare. Typical APs are out because I have a history of movement disorders on too many meds and was hospitalized this summer with movement disorder on a typical. I'm at high risk with all APs and since the typicals have a higher risk of movement disorders they aren't good for me. Which leaves Clozaril.

Clozaril and Seroquel have an interaction that can affect the heart's rhythm so they can't be mixed. So I'm going to be going IP and then will have the Seroquel removed and Clozaril started when it is safe (and they can monitor so it will be able to be used earlier).

So basically it's about running out of meds. I've been quite treatment resistant and am currently on cocktail #69 (not including all the dose adjustments over many years); clozaril will be 70 and over 40 meds tried. Clozaril also is supposed to help when nothing else does and I've never really been stable, just less cycling at times.