I can't remember, has she been hospitalized? I'm thinking some kind of adolescent unit, especially one that might keep her for a week or two, might be a beneficial thing. They'd be able to observe and adjust meds since it sounds like what's on isn't helping much. Which makes sense because lamictal helps depression more and obviously so does lexapro. She may need a mood stabilizer or an anti-psychotic to help even things out. They'd also be able to get closer to a more accurate diagnosis for you. I have a friend who went through this with her son when he was younger than your daughter and while it was really hard it completely turned his life around and he's doing so well now that nobody would believe how bad his symptoms were. I think he was even coming off some of his stronger meds lately.

There are also residential treatment facilities. I don't know much about them but I think you have to have tried hospitalization and had it not work. Those provide longer term treatment away from home so not ideal but it has helped people before.

I guess for starters though maybe ask her pdoc about a med to calm her as well as the antidepressants. ADs alone could be stimulating her and making things worse. When I was on just zoloft when I was 21 I slapped my sister. I am still horrified I did this but the zoloft was making me really manic and I wasn't sleeping making it worse and one thing led to another. This was nearly 20 years ago and I still cringe to think of it. I'm pretty sure with a mood stabilizer too it would never have been that way.