I'm on all kinds of medications and none made CBT difficult. By the way, I am nearing the end of my CBT and I look back and realize I am a different person today than before the therapy. I have had exposure to some very difficult situations that would have probably resulted in me going to the hospital. Instead, I was able to rely on the coping strategies I've learned and I was able to manage my way through the 'trials'. Don't fiddle with your meds.