I never had trouble with lamital and hypomania but I was always on it with depakote and lithium (and I still got hypomanic, just not from the lamictal). It increases the depakote level so the two cancel each other out somewhat. Although for me that meant I was sick a lot from what I think was too much lamictal (I was in a clinical trial with the combo of the 3 drugs and partway through they upped everyone's lamictal saying a higher dose was better. I started throwing up soon after and it took a while to figure out what was causing it, especially since I was done with the study and with a new pdoc about the same time.) But now they don't usually prescribe that dose that often I don't think so the further trials must have shown it was too much (and apparently that the combo I was on didn't work since it was never published).

I liked lamictal a lot the 2nd time with better dosing but I got to the end of the high risk period for the rash, was happy, and within days got the rash very badly. So, no more lamictal for me.

I did depakote for a long time and it was good at what it did, I just didn't process it well and required a huge dose which had more side effects than a normal dose (3200 mg of ER).So when Seroquel was working well I was glad to go off Depakote. But for the years I needed the stuff it was exactly what I needed.