Not really. I had a lot of nausea and daily vomiting on a high dose of lamictal plus depakote which increases the levels of one of the drugs (I think the lamictal?). After that the only nausea I had was when my lithium levels crept up, which did happen after I was toxic the first time. It seemed like I was more sensitive to it after that. But if I reacted with lots of water and some salt when I first was nauseous from lithium I was fine. Otherwise the only time I've had trouble with nausea was last summer whenever my loxapine dosage was increased I'd be sick for a few days but that drug only lasted a few months before I got EPS pretty badly and had to stop. I do take meds for GERD and that helps a lot. I'm supposed to take them BID but am a failure at AM meds so mostly only get it at night. We'll see what happens when I'm supposed to take Clozaril in the morning. Maybe I'll figure out how to handle AM meds again. I used to do it without problems and now I'm so bad at it I even take levothyroxine at night.