I was on 120mgs Cymbalta every morning for several years. Started out at 30mgs in 2007 and increased to the max dose of 120mgs over the years. It worked great for me, my depression was well controlled. In August of 2015 I was hospitalized for an eating disorder and my lab work (liver enzymes) came back extremely high. They took me off cold turkey everything that was processed by my liver. That included my cymbalta. I was so physically ill that I could not keep food down. I also started having suicidal thoughts again. They waited a week before putting me on another anti-depressant, which did not work. I am now on 25mgs of Pristiq going up to 50mgs Monday.