My pdoc expected me to notice a difference within a week too. Nothing so far and I've been on 40mg for about 4 days. I'm like, if 40mg isn't doing anything, then what will 60mg do? Plus, as always, weight is my main concern. Thankfully I haven't put on any weight this past week on it, but if it's not helping mentally, then whatever! I'm almost thinking of going off all the meds and trying to do this with natural substances. Gaba, SAM-e, etc. I know that is probably not what I should do, but it doesn't seem like prescription meds are working anyway. Plus, the only thing that is helping a little with anxiety, agitation, and boredom is walking. However, then I'm miserable from joint pain. It's like I can't win. I know, pity party!