My therapist is a guy and we talk about the effect of my hormones on my mood all the time. I always keep him really informed because I often need help in knowing whether it's likely to be monthly blues or something else- sometimes I forget when I'm in the midst of these things that it's the hormones, not the fact that the world is terribly cruel, that is entrapping me in feelings of despair and hopelessness.

I would imagine most therapists would appreciate a client bringing additional insight into their problems. That would be a drag if he saw this as challenging - I would definitely bring it up.