Before I got married my rule of thumb was IF there was going to be a third date. I always figured if they couldn't deal with it I didn't want to waste my time or their time getting invested in a relationship. You might have different standards but for me I wouldn't waste my time going on a third date with someone if I didn't see that it could lead to something permanent. So end of second date after we made plans for the third I'd say I have something i need to talk to you about....
I was always lucky and never had anyone freak out or be nasty about it. Sometimes I got a ton of questions because they wanted to know about bipolar and PTSD but fortunately no one was ever rude