Hi Jeff,

From my own experience, isolation is the worst thing to do in terms of depression. Human relationships nurture the soul. Makes sense why depression attacks most introverts than it does to extroverts. Isolation is potential dangerous for depression because it thrives off of stagnation or opposite of elevation. Comfort or stagnation literally kills your neuro-plasticity which is the brain's ability to adapt. Although there is positive stress such as eustress, depression was triggered through distress which is an emotional stress or the concept of rumination which is dwelling in the past or dwelling in the future. This is interesting to me because this means somewhere down the line, we've failed to adapt to the stress.

I personally love isolation but it's better to be outdoors. When I have a depress episode, I found that I'm more likely to overthink and over anaylze things.

It is trying to separate oneself or the ego (edge god out) that makes our suffering worse. Strength comes from the connection with the universe and with people.

I hate to say it, but maybe your friends that end the friendship are not what you call true friends. True friends are blood in blood out. A true friend realizes that the ones who are the hardest to love are the ones who need it the most. They maybe did you a favor by ending it. See the positive in the situation.

Your anxiety, which is the rumination of the future has to do with self-image and a little bit of ego. It wants to approval of others to fit in the social hierachy.

There's more I want to say as well, but my reply might be too long lol. Let me know if this helps or you would like me to elaborate more.